SCHEMBL8501119

SCHEMBL8501119

CC(C)OCCCN1CCC(O)CC1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 7/20 0.43
HRH2 P25021 1/20 0.43
HRH1 P35367 1/20 0.43
ACHE P22303 1/20 0.43
KCNA3 P22001 1/20 0.39
SPHK1 Q9NYA1 1/20 0.39
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
KCNH2 Q12809 1/20 0.38
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP2D6 P10635 1/20 0.38
RAB9A P51151 1/20 0.38
KMT2A Q03164 1/20 0.38
MAOB P27338 1/20 0.38
KDM1A O60341 1/20 0.37
SIGMAR1 Q99720 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27359356 0.93 MAOB (0.44) HRH3HRH2HRH1ACHEKCNA3
SCHEMBL9917377 0.90 HRH3 (0.49) HRH3HRH2HRH1
SCHEMBL21667892 0.90 HRH3 (0.49) HRH3HRH2HRH1
SCHEMBL9917378 0.90 HRH3 (0.49) HRH3HRH2HRH1
SCHEMBL9911412 0.89 KDM1A (0.45) HRH3HRH2HRH1ACHEKCNA3
SCHEMBL22890929 0.85 HRH3 (0.41) HRH3HRH2HRH1ACHEKCNA3
SCHEMBL22890951 0.84 KDM1A (0.38) HRH3MEN1ALDH1A1KMT2AMAOB
SCHEMBL20698611 0.84 HRH3 (0.43) HRH3MEN1KMT2AKDM1ASIGMAR1
SCHEMBL25492956 0.84 SIGMAR1 (0.50) HRH3HRH2HRH1MEN1ALDH1A1
SCHEMBL26741730 0.82 MEN1 (0.41) HRH3HRH2HRH1MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4272825-A2 MTORC MODULATORS AND USES THEREOF Aeovian Pharmaceuticals, Inc. (US) 2023-11-08 EP disclosed
US-20230331737-A1 MTORC1 MODULATORS AND USES THEREOF AEOVIAN PHARMACEUTICALS, INC. 2023-10-19 US disclosed
US-20230331737-A1 MTORC1 MODULATORS AND USES THEREOF AEOVIAN PHARMACEUTICALS, INC. 2023-10-19 US disclosed
US-11759458-B2 Indane-amines as PD-L1 antagonists CHEMOCENTRYX, INC. (US) 2023-09-19 US disclosed
US-11759458-B2 Indane-amines as PD-L1 antagonists CHEMOCENTRYX, INC. (US) 2023-09-19 US disclosed
US-11708326-B2 Immunomodulator compounds CHEMOCENTRYX, INC. (US) 2023-07-25 US disclosed
US-11708326-B2 Immunomodulator compounds CHEMOCENTRYX, INC. (US) 2023-07-25 US disclosed
US-11702429-B2 mTORC modulators and uses thereof AEOVIAN PHARMACEUTICALS, INC. (US) 2023-07-18 US disclosed
US-11702429-B2 mTORC modulators and uses thereof AEOVIAN PHARMACEUTICALS, INC. (US) 2023-07-18 US disclosed
US-11691985-B2 Macrocyclic immunomodulators CHEMOCENTRYX, INC. (US) 2023-07-04 US disclosed
WO-2020154447-A1 MTORC MODULATORS AND USES THEREOF AEOVIAN PHARMACEUTICALS, INC. (US) 2020-07-30 WO disclosed
WO-2019165043-A2 INDANE-AMINES AS PD-L1 ANTAGONISTS CHEMOCENTRYX, INC. (US) 2019-08-29 WO disclosed
US-10392405-B2 Macrocyclic immunomodulators CHEMOCENTRYX, INC. (US) 2019-08-27 US disclosed
US-20190144389-A1 DEUTERATED COMPOUNDS AS IMMUNOMODULATORS CHEMOCENTRYX, INC. 2019-05-16 US disclosed
US-20190135745-A1 IMMUNOMODULATOR COMPOUNDS CHEMOCENTRYX, INC. 2019-05-09 US disclosed
WO-2019032547-A1 MACROCYCLIC IMMUNOMODULATORS CHEMOCENTRYX, INC. (US) 2019-02-14 WO disclosed
US-20190048022-A1 MACROCYCLIC IMMUNOMODULATORS CHEMOCENTRYX, INC. 2019-02-14 US disclosed
EP-0784620-B1 N-SUBSTITUTED PIPERIDINYL BICYCLIC BENZOATE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 1999-12-08 EP disclosed
EP-0784620-A1 N-SUBSTITUTED PIPERIDINYL BICYCLIC BENZOATE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1997-07-23 EP disclosed
WO-1996010027-A1 N-SUBSTITUTED PIPERIDINYL BICYCLIC BENZOATE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1996-04-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190135745-A1 IMMUNOMODULATOR COMPOUNDS IL2, FCGRT, IFNG HRH3 143/4885HRH2 110/4885HRH1 166/4885
US-11708326-B2 Immunomodulator compounds IL2, FCGRT, IFNG HRH3 143/4885HRH2 110/4885HRH1 166/4885
US-20190144389-A1 DEUTERATED COMPOUNDS AS IMMUNOMODULATORS C3AR1, C5AR1, C5AR2 HRH3 14/4885HRH2 38/4885HRH1 29/4885
US-11702429-B2 mTORC modulators and uses thereof MTOR, RICTOR, RPTOR HRH3 3363/4885HRH2 3574/4885HRH1 3452/4885
US-11691985-B2 Macrocyclic immunomodulators IL2, IL2RA, C3AR1 HRH3 162/4885HRH2 158/4885HRH1 234/4885
US-20190048022-A1 MACROCYCLIC IMMUNOMODULATORS IL2, IL2RA, C3AR1 HRH3 162/4885HRH2 158/4885HRH1 234/4885
US-10392405-B2 Macrocyclic immunomodulators IL2, IL2RA, C3AR1 HRH3 162/4885HRH2 158/4885HRH1 234/4885
US-20230331737-A1 MTORC1 MODULATORS AND USES THEREOF MTOR, RPTOR, RICTOR HRH3 3604/4885HRH2 3841/4885HRH1 3419/4885
US-11759458-B2 Indane-amines as PD-L1 antagonists CD274, PDCD1LG2, PDCD1 HRH3 11/4885HRH2 21/4885HRH1 18/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.