Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8501620 | 0.90 | MAOB (0.53) | PDGFRBPDGFRAMAPTKMT2ANPC1 | |
| SCHEMBL8503241 | 0.81 | KMT2A (0.50) | PDGFRBPDGFRAMAPTKMT2ANPC1 | |
| SCHEMBL8501414 | 0.81 | PDE3B (0.58) | PDGFRBPDGFRA | |
| SCHEMBL8499652 | 0.79 | PPARG (0.54) | PDGFRBPDGFRAMAOBGRIN2BMAP4K4 | |
| SCHEMBL8499648 | 0.79 | PDE3B (0.55) | PDGFRBPDGFRA | |
| SCHEMBL8502489 | 0.78 | PDGFRB (0.52) | PDGFRBPDGFRAMAOBGRIN2BMAP4K4 | |
| SCHEMBL8887119 | 0.78 | PDGFRB (0.47) | PDGFRBPDGFRAGRIN2BMAP4K4CSNK1G2 | |
| SCHEMBL8502972 | 0.78 | PDGFRB (0.46) | PDGFRBPDGFRAMAPTKMT2ANPC1 | |
| SCHEMBL27616493 | 0.77 | KMT2A (0.50) | PDGFRBPDGFRAMAPTKMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL8504144 | 0.77 | PDGFRB (0.51) | PDGFRBPDGFRAMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |