Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.54 |
| ▸ | PPARA | Q07869 | 9/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887119 | 0.82 | PDGFRB (0.47) | PPARGPPARAPDGFRBPDGFRAMAP4K4 | |
| SCHEMBL8887112 | 0.80 | PDGFRB (0.45) | PPARGPPARAPDGFRBPDGFRADPP4 | |
| SCHEMBL8501205 | 0.79 | PDGFRB (0.51) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8499648 | 0.77 | PDE3B (0.55) | PPARGPPARAPDGFRBPDGFRA | |
| SCHEMBL8503241 | 0.75 | KMT2A (0.50) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8501414 | 0.74 | PDE3B (0.58) | PPARGPPARAPDGFRBPDGFRA | |
| SCHEMBL8501209 | 0.74 | AKR1C3 (0.60) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8889522 | 0.74 | PDGFRB (0.47) | PPARGPPARAPDGFRBPDGFRAMAP4K4 | |
| SCHEMBL8502489 | 0.74 | PDGFRB (0.52) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8887303 | 0.73 | DCLRE1B (0.58) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |