Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 4/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856471 | 0.91 | TP53 (0.45) | LMNAF2TMPRSS6CASRPRMT5 | |
| SCHEMBL7379927 | 0.82 | KMT2A (0.45) | LMNAF2NPC1RAB9AMEN1 | |
| SCHEMBL7453096 | 0.82 | LMNA (0.48) | LMNAPAX8KDM1ANPC1RAB9A | |
| SCHEMBL7856464 | 0.78 | TP53 (0.49) | LMNATP53TSHRMEN1GAA | |
| SCHEMBL7453103 | 0.76 | LMNA (0.51) | LMNAPAX8KDM1ANPC1RAB9A | |
| SCHEMBL7380397 | 0.76 | CASR (0.47) | PAX8F2NPC1RAB9ACASR | |
| SCHEMBL7856536 | 0.74 | LMNA (0.54) | LMNAF10NPC1RAB9A | |
| SCHEMBL8500653 | 0.74 | ITGB3 (0.60) | LMNAF10NPC1RAB9A | |
| SCHEMBL6778195 | 0.73 | ITGB3 (0.43) | F2CASRMEN1KMT2A | |
| SCHEMBL6773735 | 0.72 | TP53 (0.39) | F2RAB9ACASRPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |