Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500430 | 0.91 | PPARG (0.39) | PPARGPPARAGPR84CYP2C19ESR1 | |
| SCHEMBL8501044 | 0.90 | AKR1C3 (0.43) | APPCYP2C19ESR1ESR2KDM4E | |
| SCHEMBL8500328 | 0.89 | AKR1C3 (0.42) | APPCYP2C19ESR1ESR2MEN1 | |
| SCHEMBL8499017 | 0.88 | AKR1C3 (0.39) | PPARGPPARAMEN1KMT2AKDM4E | |
| SCHEMBL8498119 | 0.87 | ESR1 (0.43) | APPCYP2C19ESR1ESR2MEN1 | |
| SCHEMBL8497557 | 0.85 | APP (0.54) | PPARGPPARAGPR84APPCYP2C19 | |
| SCHEMBL8501228 | 0.84 | AKR1C3 (0.44) | APPCYP2C19ESR1ESR2KDM4E | |
| SCHEMBL8500221 | 0.84 | MCL1 (0.35) | PPARGPPARAESR2ABCG2MCL1 | |
| SCHEMBL8500302 | 0.83 | AKR1C3 (0.45) | GPR84CYP2C19 | |
| SCHEMBL8499729 | 0.83 | ESR1 (0.42) | PPARGPPARAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |