Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 19/20 | 0.77 |
| ▸ | EDNRB | P24530 | 13/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152582 | 0.87 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL4630639 | 0.79 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7252302 | 0.77 | EDNRA (0.76) | EDNRAEDNRB | |
| SCHEMBL7989880 | 0.77 | EDNRA (0.82) | EDNRAEDNRB | |
| SCHEMBL4631401 | 0.76 | EDNRA (0.81) | EDNRAEDNRB | |
| SCHEMBL4630724 | 0.75 | EDNRA (0.79) | EDNRAEDNRB | |
| SCHEMBL7700723 | 0.74 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL4631800 | 0.74 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL4631504 | 0.74 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL6151317 | 0.73 | EDNRA (0.80) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962490-A | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-10-05 | — | — | US | disclosed |