Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210197 | 0.85 | FBP1 (0.51) | KDRFBP1FGFR1FLT1 | |
| SCHEMBL7205577 | 0.84 | KDR (0.46) | KDREGFRFGFR1FLT1 | |
| SCHEMBL7205793 | 0.82 | KDR (0.48) | KDRFBP1FGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL7209976 | 0.82 | KDR (0.47) | KDRGAKEGFR | |
| SCHEMBL4518666 | 0.81 | PDGFRB (0.46) | KDREGFRFGFR1FLT1 | |
| SCHEMBL7207079 | 0.81 | KDR (0.44) | KDREGFR | |
| SCHEMBL7211312 | 0.81 | KDR (0.42) | KDREGFRFGFR1FLT1 | |
| SCHEMBL7205822 | 0.81 | BRAF (0.46) | KDRFBP1EGFRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL7212863 | 0.81 | KDR (0.42) | KDREGFRFGFR1FLT1 | |
| SCHEMBL7211368 | 0.81 | ABCG2 (0.43) | KDRFBP1FGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |