Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 8/20 | 0.64 |
| ▸ | HTR7 | P34969 | 3/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL85004 | 0.93 | HTR2A (0.62) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL21633562 | 0.89 | HTR2A (0.60) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL23595908 | 0.87 | HTR2A (0.59) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL10634285 | 0.85 | HTR2A (0.55) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL84999 | 0.85 | HTR2A (0.64) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL84567 | 0.84 | HTR2A (0.55) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL84566 | 0.83 | DRD2 (0.70) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL85565 | 0.83 | HTR2A (0.62) | DRD2HTR2AHTR7KCNH2HTR1A | |
| SCHEMBL19957359 | 0.83 | DRD2 (0.66) | DRD2SLC6A4HTR2AHTR7HTR1A | |
| SCHEMBL24668871 | 0.81 | HTR2A (0.78) | DRD2HTR2AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129410-B2 | Sleep maintenance insomnia; circadian rhythm abnormalities; side effect reduction | HYPNION, INC. (US) | 2012-03-06 | — | — | US | disclosed |