SCHEMBL8501693

SCHEMBL8501693

COc1cc(OCc2ccccc2)ccc1C(=O)c1cc(Cl)ccc1N

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PARP15 Q460N3 3/20 0.51
SMN1; SMN2 Q16637 2/20 0.50
MAPT P10636 1/20 0.50
MAOB P27338 5/20 0.48
PARP10 Q53GL7 2/20 0.47
MAOA P21397 3/20 0.46
RECQL P46063 1/20 0.46
PTGER1 P34995 1/20 0.46
KDM4E B2RXH2 1/20 0.45
NPC1 O15118 1/20 0.45
GAA P10253 1/20 0.45
RAB9A P51151 1/20 0.45
ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2705226 0.84 NPC1 (0.56) SMN1; SMN2MAPTRECQLNPC1RAB9A
SCHEMBL6957797 0.82 PTGER1 (0.58) RECQLPTGER1KDM4ENPC1
SCHEMBL30343022 0.80 MAOB (0.58) PARP15SMN1; SMN2MAOBPARP10KDM4E
SCHEMBL6140955 0.80 PARP15 (0.75) PARP15SMN1; SMN2MAOBPARP10KDM4E
SCHEMBL10373885 0.80 MAOB (0.58) PARP15SMN1; SMN2MAOBPARP10KDM4E
SCHEMBL1448026 0.79 MAOB (0.61) PARP15SMN1; SMN2MAOBPARP10KDM4E
SCHEMBL16016781 0.79 MAOB (0.63) SMN1; SMN2MAOBPARP10NPC1RAB9A
SCHEMBL31591489 0.78 MAOA (0.61) PARP15SMN1; SMN2MAOBMAOANPC1
SCHEMBL10797158 0.78 MAOB (0.72) PARP15SMN1; SMN2MAPTMAOBPARP10
SCHEMBL11283190 0.78 MAOB (0.59) PARP15SMN1; SMN2MAOBPARP10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5885979-A SQUALENE SYNTHETASE INHIBITOR TREATING OR PREVENTING HYPERLIPIDEMIA TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-03-23 US disclosed
US-5726306-A INHIBITORS OF SQUALENE SYNTHETASE AND FUNGAL GROWTH; USEFUL IN TREATING AND PREVENTING HYPERLIPIDEMIA TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-10 US disclosed
WO-1995021834-A1 OPTICALLY ACTIVE 4,1-BENZOXAZEPINE DERIVATIVES USEFUL AS SQUALENE SYNTHASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-08-17 WO disclosed