Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 6/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953541 | 0.84 | RECQL (0.60) | RECQLKMT2ANPC1 | |
| SCHEMBL5528744 | 0.84 | RECQL (0.60) | PTGER1RECQLKMT2AKDM4ENPC1 | |
| SCHEMBL9696207 | 0.83 | SGMS2 (0.66) | PTGER1KMT2AHTTSGMS2PARP1 | |
| SCHEMBL8501693 | 0.82 | PARP15 (0.51) | PTGER1RECQLKDM4ENPC1 | |
| SCHEMBL3729989 | 0.81 | PTGER1 (0.64) | PTGER1KMT2ALRRK2PARP1PARP2 | |
| SCHEMBL487486 | 0.80 | PTGER1 (0.75) | PTGER1KMT2ALRRK2KDM4ECYP2C9 | |
| SCHEMBL27336880 | 0.80 | PTGER1 (0.62) | PTGER1KMT2ALRRK2CYP2C9 | |
| SCHEMBL12165498 | 0.80 | RECQL (0.61) | RECQLKMT2AHTTKDM4ECYP2C9 | |
| SCHEMBL2705425 | 0.79 | RECQL (0.65) | RECQLKDM4ENPC1 | |
| SCHEMBL5460706 | 0.79 | PTGER1 (0.65) | PTGER1KMT2ALRRK2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567026-B1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5885979-A | SQUALENE SYNTHETASE INHIBITOR TREATING OR PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5726306-A | INHIBITORS OF SQUALENE SYNTHETASE AND FUNGAL GROWTH; USEFUL IN TREATING AND PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0567026-A1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |