Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501749 | 0.82 | TLR8 (0.46) | TLR8TLR7PDPK1LOXL2METAP1 | |
| SCHEMBL8499704 | 0.82 | TLR8 (0.41) | TLR8TLR7PDPK1LOXL2METAP1 | |
| SCHEMBL17493786 | 0.73 | PDE3B (0.49) | PDPK1CHEK1 | |
| SCHEMBL9959860 | 0.72 | TLR8 (0.47) | TLR8TLR7PDPK1LOXL2METAP1 | |
| SCHEMBL8094750 | 0.72 | PDPK1 (0.42) | TLR8TLR7PDPK1LOXL2METAP1 | |
| SCHEMBL13142475 | 0.71 | PDPK1 (0.57) | PDPK1LOXL2METAP1ADRB2CYP2A6 | |
| SCHEMBL9095521 | 0.71 | GUSB (0.51) | PDPK1LOXL2 | |
| SCHEMBL8088436 | 0.71 | PDE10A (0.44) | TLR8TLR7PDPK1LOXL2METAP1 | |
| SCHEMBL8499706 | 0.71 | PDE10A (0.44) | TLR8TLR7PDPK1LOXL2METAP1 | |
| SCHEMBL26259866 | 0.70 | PDPK1 (0.55) | TLR8TLR7PDPK1LOXL2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946559-A2 | IMIDAZOPYRIDAZINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028299-A2 | IMIDAZOPYRIDAZINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-07-02 | — | — | WO | disclosed |