Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 7/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | WDR5 | P61964 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501299 | 0.89 | CYP2C9 (0.55) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL14237996 | 0.88 | CYP2C9 (0.48) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL14648552 | 0.88 | CYP2C9 (0.50) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8503057 | 0.87 | CYP2C9 (0.53) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8504230 | 0.87 | CYP2C9 (0.53) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL14648549 | 0.86 | CYP2C9 (0.48) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL29538889 | 0.86 | RAB9A (0.71) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1306777 | 0.86 | RAB9A (0.71) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5738053 | 0.85 | RAB9A (0.70) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5738051 | 0.85 | RAB9A (0.70) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998445-A | PEPTIC ULCERS | EISAI CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| US-5840910-A | Pyridine derivatives having anti-ulcerative activity | ESAI CO., LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0268956-B2 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | EISAI CO LTD (JP) | 1998-04-15 | — | — | EP | disclosed |
| EP-0786461-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | Eisai Co., Ltd. (JP) | 1997-07-30 | — | — | EP | disclosed |
| EP-0654471-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and process for preparing the same | Eisai Co., Ltd. (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0475456-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | Eisai Co., Ltd. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-5045552-A | Pyridine derivatives having anti-ulcerative activity | EISAI CO., LTD. (JP) | 1991-09-03 | — | — | US | disclosed |