Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 9/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | WDR5 | P61964 | 2/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | IDE | P14735 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501930 | 0.88 | CYP2C9 (0.53) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL14648554 | 0.88 | CYP1A2 (0.53) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL8501299 | 0.85 | CYP2C9 (0.55) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL14237996 | 0.85 | CYP2C9 (0.48) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL12438588 | 0.85 | CYP1A2 (0.71) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL8503057 | 0.83 | CYP2C9 (0.53) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL8504230 | 0.83 | CYP2C9 (0.53) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL14648549 | 0.83 | CYP2C9 (0.48) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL29538889 | 0.83 | RAB9A (0.71) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL1306777 | 0.83 | RAB9A (0.71) | CYP2C9CYP2D6CYP2C19CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176892-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD. (CN) | 2016-06-23 | — | — | US | disclosed |
| US-20160176892-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD. (CN) | 2016-06-23 | — | — | US | disclosed |
| US-9315513-B2 | Benzimidazole derivatives and their pharmaceutical compositions and uses | Xuanzhu Pharma Co., Ltd. (CN) | 2016-04-19 | — | — | US | disclosed |
| US-9315513-B2 | Benzimidazole derivatives and their pharmaceutical compositions and uses | Xuanzhu Pharma Co., Ltd. (CN) | 2016-04-19 | — | — | US | disclosed |
| US-20130023568-A1 | Benzimidazole Derivatives And Their Pharmaceutical Compositions And Uses | Xuanzhu Pharma Co., Ltd. (CN) | 2013-01-24 | — | — | US | disclosed |
| US-20130023568-A1 | Benzimidazole Derivatives And Their Pharmaceutical Compositions And Uses | Xuanzhu Pharma Co., Ltd. (CN) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176892-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES | F12, HRH2, H1-3 | CYP2C9 94/4885CYP2D6 152/4885CYP2C19 37/4885 |
| US-20130023568-A1 | Benzimidazole Derivatives And Their Pharmaceutical Compositions And Uses | F12, HRH2, H1-3 | CYP2C9 94/4885CYP2D6 152/4885CYP2C19 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.