Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.54 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8926104 | 0.85 | PLA2G2A (0.58) | PLA2G2AICMT | |
| SCHEMBL2156634 | 0.81 | PLA2G2A (0.79) | PLA2G2A | |
| SCHEMBL8503352 | 0.80 | PLA2G2A (0.52) | PLA2G2ASERPINE1ADORA1L3MBTL1F2RL3 | |
| SCHEMBL8505760 | 0.78 | HDAC11 (0.45) | — | |
| SCHEMBL8503359 | 0.77 | PLA2G2A (0.61) | PLA2G2ASERPINE1ADORA1L3MBTL1ICMT | |
| SCHEMBL8925308 | 0.76 | PLA2G2A (0.60) | PLA2G2A | |
| SCHEMBL8924952 | 0.76 | PLA2G2A (0.59) | PLA2G2A | |
| SCHEMBL8926151 | 0.75 | PLA2G2A (0.59) | PLA2G2A | |
| SCHEMBL8924855 | 0.74 | PLA2G2A (0.61) | PLA2G2A | |
| SCHEMBL8505410 | 0.73 | PLA2G2A (0.54) | PLA2G2ASERPINE1ADORA1L3MBTL1ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919810-A | SEPTIC SHOCK | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5919943-A | INHIBITION OF SPLA2 | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5733923-A | SECRETORY PANCREATIC PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |