Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8505413 | 0.91 | PLA2G2A (0.64) | PLA2G2ALMNAALDH1A1SERPINE1L3MBTL1 | |
| SCHEMBL8926105 | 0.85 | PLA2G2A (0.70) | PLA2G2AICMT | |
| SCHEMBL2156634 | 0.81 | PLA2G2A (0.79) | PLA2G2A | |
| SCHEMBL8503352 | 0.79 | PLA2G2A (0.52) | PLA2G2ALMNAALDH1A1SERPINE1L3MBTL1 | |
| SCHEMBL8503354 | 0.77 | PLA2G2A (0.54) | PLA2G2ALMNAALDH1A1SERPINE1L3MBTL1 | |
| SCHEMBL8505763 | 0.77 | HDAC6 (0.47) | — | |
| SCHEMBL2156832 | 0.76 | PLA2G2A (1.00) | PLA2G2ASERPINE1 | |
| SCHEMBL8926520 | 0.75 | PLA2G2A (0.74) | PLA2G2AICMT | |
| SCHEMBL8925313 | 0.75 | PLA2G2A (0.71) | PLA2G2A | |
| SCHEMBL8924962 | 0.74 | PLA2G2A (0.70) | PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919810-A | SEPTIC SHOCK | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5919943-A | INHIBITION OF SPLA2 | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5733923-A | SECRETORY PANCREATIC PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |