Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.36 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.36 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL476218 | 0.91 | TDP1 (0.44) | TDP1TSHRCHRM5CHRM1CHRM3 | |
| Acrylamide SCHEMBL134959 | 0.91 | TSHR (0.48) | TSHRALDH1A1FGFR4CHRM5CHRM1 | |
| Acrylamide SCHEMBL28603972 | 0.91 | TSHR (0.48) | TSHRALDH1A1FGFR4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL475879 | 0.91 | TDP1 (0.52) | TDP1TSHRCHRM5CHRM1CHRM3 | |
| Acrylic Acid SCHEMBL12076053 | 0.90 | TDP1 (0.40) | TDP1TSHRCHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL27532640 | 0.89 | TDP1 (0.50) | TDP1TSHRCHRM5CHRM1CHRM3 | |
| Water SCHEMBL28456913 | 0.89 | TDP1 (0.50) | TDP1TSHRCHRM5CHRM1CHRM3 | |
| SCHEMBL565786 | 0.89 | TDP1 (0.55) | TDP1TSHRCHRM5CHRM1CHRM3 | |
| Acrylamide SCHEMBL3636541 | 0.89 | TSHR (0.50) | TSHRALDH1A1FGFR4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL28084523 | 0.87 | TDP1 (0.48) | TDP1TSHRCHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108774294-B | Preparation method of ternary copolymerization cationic polyacrylamide | 中科乐美环保科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| US-5888666-A | Secondary battery | CANON KABUSHIKI KAISHA (JP) | 1999-03-30 | — | — | US | disclosed |