Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 13/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8506683 | 0.97 | DRD1 (0.55) | DRD1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8504083 | 0.76 | SLC6A2 (0.58) | DRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11458918 | 0.76 | SLC6A2 (0.53) | DRD1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2571100 | 0.75 | SLC6A2 (0.71) | DRD1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8504203 | 0.75 | DRD1 (0.60) | DRD1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13928820 | 0.74 | SLC6A2 (0.62) | DRD1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16263409 | 0.73 | DRD1 (0.72) | DRD1HTR2AMAPK1THPOHIF1A | |
| SCHEMBL9764352 | 0.72 | SLC6A2 (0.74) | DRD1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14533569 | 0.71 | DRD1 (0.80) | DRD1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9193250 | 0.71 | DRD1 (0.67) | DRD1HTR2AMAPK1THPOHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0688320-B1 | TRICYCLIC BENZODIAZEPINS, THEIR USE AND PREPARATION | NOVO NORDISK AS (DK) | 1999-05-06 | — | — | EP | claimed |
| EP-0688320-B1 | TRICYCLIC BENZODIAZEPINS, THEIR USE AND PREPARATION | NOVO NORDISK AS (DK) | 1999-05-06 | — | — | EP | disclosed |
| EP-0688320-A1 | TRICYCLIC BENZODIAZEPINS, THEIR USE AND PREPARATION | NOVO NORDISK A/S (DK) | 1995-12-27 | — | — | EP | disclosed |
| WO-1994020472-A1 | HETEROCYCLIC COMPOUNDS, THEIR USE AND PREPARATION | NOVO NORDISK A/S (DK) | 1994-09-15 | — | — | WO | disclosed |