Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8505557 | 0.84 | MAPK1 (0.51) | KDM4EALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL8503374 | 0.81 | CYP1A2 (0.45) | KDM4EALDH1A1MAPTNPSR1PLA2G2A | |
| SCHEMBL8502665 | 0.80 | MAPT (0.45) | KDM4EALDH1A1MAPTNPSR1HTT | |
| SCHEMBL8504259 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL2157708 | 0.77 | PLA2G2A (0.50) | KDM4EALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL3048393 | 0.76 | KMT2A (0.46) | ALDH1A1KMT2AMEN1GAAHPGD | |
| SCHEMBL2157299 | 0.76 | MEN1 (0.50) | KDM4EALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL2156667 | 0.75 | F10 (0.47) | KDM4EALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL8505425 | 0.73 | PLA2G2A (0.45) | KDM4EALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL8502662 | 0.72 | MTNR1A (0.52) | KDM4EALDH1A1MAPTPLA2G2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919943-A | INHIBITION OF SPLA2 | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5919810-A | SEPTIC SHOCK | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5733923-A | SECRETORY PANCREATIC PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |