SCHEMBL8504469

SCHEMBL8504469

Cc1ccc(NS(=O)(=O)c2ccccc2)n1-c1ccc(F)cc1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.48
PTGS2 P35354 1/20 0.47
MAPT P10636 2/20 0.46
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
PKM P14618 1/20 0.46
KMT2A Q03164 1/20 0.46
RAB9A P51151 1/20 0.46
GAA P10253 1/20 0.45
MAPK1 P28482 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
KEAP1 Q14145 1/20 0.44
NFE2L2 Q16236 1/20 0.44
CYP2C9 P11712 1/20 0.43
FFAR4 Q5NUL3 2/20 0.43
OXTR P30559 1/20 0.43
FFAR1 O14842 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8502466 0.90 CYP2C9 (0.53) TSHRPTGS2MEN1ALDH1A1PKM
SCHEMBL8504989 0.88 CYP2C9 (0.53) PTGS2MAPTMEN1ALDH1A1PKM
SCHEMBL8506063 0.86 CYP2C9 (0.51) MEN1ALDH1A1PKMKMT2AGAA
SCHEMBL8502313 0.86 ALDH1A1 (0.49) MEN1ALDH1A1PKMKMT2AGAA
SCHEMBL8505563 0.85 PTGS2 (0.50) TSHRPTGS2ALDH1A1PKMKMT2A
SCHEMBL8506143 0.85 PTGS2 (0.50) PTGS2MAPTMEN1ALDH1A1KMT2A
SCHEMBL8504978 0.83 ALDH1A1 (0.50) TSHRMAPTMEN1ALDH1A1PKM
SCHEMBL8503404 0.83 POLB (0.56) MAPTMEN1ALDH1A1PKMKMT2A
SCHEMBL8504133 0.83 KLKB1 (0.43) TSHRALDH1A1PKMKMT2AGAA
SCHEMBL8505516 0.83 CYP2C9 (0.50) TSHRMEN1ALDH1A1KMT2ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5935990-A PYRROLYL DERIVATIVES HAVING AT POSITION 1 OR 5 A PHENYL SUBSTITUTED WITH METHYLSULFONYL OR AMINOSULFONYL; INHIBIT CYCLOOXYGENASE-2 FOR USE TREATMENT OF INFLAMMATION, AS AN ANALGESIC, OR AS AN ANTIPYRETIC G.D. SEARLE & CO. (US) 1999-08-10 US claimed
US-5935990-A PYRROLYL DERIVATIVES HAVING AT POSITION 1 OR 5 A PHENYL SUBSTITUTED WITH METHYLSULFONYL OR AMINOSULFONYL; INHIBIT CYCLOOXYGENASE-2 FOR USE TREATMENT OF INFLAMMATION, AS AN ANALGESIC, OR AS AN ANTIPYRETIC G.D. SEARLE & CO. (US) 1999-08-10 US disclosed