Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 14/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 8/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | THPO | P40225 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504189 | 0.88 | SLC6A2 (0.62) | DRD1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL8504083 | 0.82 | SLC6A2 (0.58) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL8504160 | 0.80 | DRD1 (0.53) | DRD1SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL8504024 | 0.80 | DRD1 (0.53) | DRD1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL29602922 | 0.79 | DRD1 (1.00) | DRD1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL29507713 | 0.79 | DRD1 (1.00) | DRD1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL5138043 | 0.79 | DRD1 (1.00) | DRD1SLC6A2SLC6A4SLC6A3DRD2 | |
| Hydrochloric Acid SCHEMBL7267588 | 0.76 | DRD1 (0.52) | DRD1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL4308075 | 0.75 | SLC6A2 (0.67) | DRD1SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL8506306 | 0.74 | DRD1 (0.42) | DRD1DRD2HTR2ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0688320-B1 | TRICYCLIC BENZODIAZEPINS, THEIR USE AND PREPARATION | NOVO NORDISK AS (DK) | 1999-05-06 | — | — | EP | disclosed |
| US-5512562-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOSIS, DEPRESSION, SLEEP DISORDERS, PARKINSON*S DISEASE, STROKE | NOVO NORDISK A/S (DK) | 1996-04-30 | — | — | US | disclosed |
| EP-0688320-A1 | TRICYCLIC BENZODIAZEPINS, THEIR USE AND PREPARATION | NOVO NORDISK A/S (DK) | 1995-12-27 | — | — | EP | disclosed |
| WO-1994020472-A1 | HETEROCYCLIC COMPOUNDS, THEIR USE AND PREPARATION | NOVO NORDISK A/S (DK) | 1994-09-15 | — | — | WO | disclosed |