Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504242 | 0.79 | LMNA (0.49) | HTR2ALMNASIGMAR1KDM1AEBP | |
| SCHEMBL8505464 | 0.78 | LMNA (0.44) | LMNASIGMAR1KDM1AEBPMAPK1 | |
| SCHEMBL8506210 | 0.77 | LMNA (0.37) | HTR2ALMNASIGMAR1KDM1AEBP | |
| SCHEMBL8507603 | 0.76 | LMNA (0.64) | HTR2ALMNASIGMAR1MEN1KMT2A | |
| SCHEMBL19505650 | 0.74 | LMNA (0.63) | HTR2ALMNASIGMAR1KDM1AEBP | |
| SCHEMBL9280563 | 0.71 | SIGMAR1 (0.44) | HTR2ASIGMAR1KDM1AEBPMAOB | |
| SCHEMBL7330436 | 0.71 | SIGMAR1 (0.44) | HTR2ASIGMAR1KDM1AEBPMAOB | |
| SCHEMBL7782464 | 0.70 | ESR2 (0.48) | LMNASIGMAR1KDM1AEBPMAOB | |
| SCHEMBL8256736 | 0.69 | LMNA (0.53) | HTR2ALMNAKDM1AMAOBMEN1 | |
| Ammonia Solution, Strong SCHEMBL27550700 | 0.69 | ESR2 (0.47) | LMNASIGMAR1KDM1AEBPMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733035-B1 | TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORP (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0733035-A1 | TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5538986-A | INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA, DIBENZOCYCLOHEPTANE AND DIBENZOXEPINE DERIVATIVES | SCHERING CORPORATION (US) | 1996-07-23 | — | — | US | disclosed |
| WO-1995015939-A1 | TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |