Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507425 | 1.00 | ALDH1A1 (0.39) | ALDH1A1LMNAALOX15HSD17B10TSHR | |
| SCHEMBL14498317 | 0.71 | — | — | |
| SCHEMBL10492901 | 0.69 | — | — | |
| SCHEMBL8762992 | 0.69 | — | — | |
| Acrylic Acid SCHEMBL27511838 | 0.69 | ALDH1A1 (0.59) | ALDH1A1LMNAALOX15HSD17B10TSHR | |
| SCHEMBL10791806 | 0.69 | ALDH1A1 (0.47) | ALDH1A1LMNAALOX15HSD17B10TSHR | |
| SCHEMBL28472216 | 0.68 | ALDH1A1 (0.46) | ALDH1A1LMNATSHRHCAR2KEAP1 | |
| Acrylic Acid Methyl Ester SCHEMBL502518 | 0.67 | HCAR2 (0.48) | ALDH1A1LMNAALOX15HSD17B10TSHR | |
| SCHEMBL896153 | 0.67 | ALDH1A1 (0.45) | ALDH1A1LMNAALOX15HSD17B10TSHR | |
| SCHEMBL27554125 | 0.67 | ALDH1A1 (0.45) | ALDH1A1LMNAALOX15HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981525-A | FOR THERAPY OR PROPHYLAXIS OF OSTEOPOROSIS,TUMOURS, ULCERS, AUTOIMMUNE DISEASES, LIPIDEMIC DISORDERS, HYPERCHOLESTEROLEMIC AND ATHEROSCLEROTIC DISEASES, AIDS ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |