Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 1.00 |
| ▸ | ACVR1 | Q04771 | 2/20 | 1.00 |
| ▸ | PDGFRA | P16234 | 1/20 | 1.00 |
| ▸ | FER | P16591 | 1/20 | 1.00 |
| ▸ | LTK | P29376 | 1/20 | 1.00 |
| ▸ | CDK8 | P49336 | 1/20 | 1.00 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.69 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.62 |
| ▸ | ROS1 | P08922 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6299954 | 0.98 | LRRK2 (0.95) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL2420711 | 0.95 | LRRK2 (0.90) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL366728 | 0.95 | — | — | |
| SCHEMBL28886187 | 0.86 | LRRK2 (0.75) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL11485594 | 0.85 | LRRK2 (0.73) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL28740919 | 0.84 | LRRK2 (0.72) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL8507659 | 0.83 | CSNK1G1 (0.72) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL8204226 | 0.83 | CHEK1 (0.72) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL3408793 | 0.83 | LRRK2 (0.69) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL1368761 | 0.83 | CHEK1 (1.00) | LRRK2ACVR1PDGFRAFERLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 226 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059085-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES | INVEA THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | claimed |
| CN-116987040-A | Dibenzodiazepine derivative and preparation method and application thereof | 中国中医科学院中药研究所 | 2023-11-03 | — | — | CN | claimed |
| WO-2019173761-A1 | C-ABL TYROSINE KINASE INHIBITORY COMPOUND EMBODIMENTS AND METHODS OF MAKING AND USING THE SAME | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-09-12 | — | — | WO | claimed |
| US-8202989-B2 | One step process for the preparation of substituted 5, 10-dihydrodibenzo [b,e][1, 4]diazepine-11-ones | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-06-19 | — | — | US | claimed |
| US-20100228023-A1 | ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2010-09-09 | — | — | US | claimed |
| EP-1540329-A4 | DRUG DISCOVERY METHOD | KEDDEM BIO SCIENCE LTD (IL) | 2009-06-10 | — | — | EP | claimed |
| US-20070197502-A1 | AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS | EK FREDRIK | 2007-08-23 | — | — | US | claimed |
| US-20060252744-A1 | Use of N-desmethylclozapine and related compounds as dopamine stabilizing agents | ACADIA PHARMACEUTICALS INC. | 2006-11-09 | — | — | US | claimed |
| JP-2006507480-A | — | — | 2006-03-02 | — | — | JP | claimed |
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | claimed |
| WO-2004010136-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2004-01-29 | — | — | WO | claimed |
| EP-0139627-B1 | Process for the preparation of 5,10-dihydro-1H-dibenzo [B,E] [1,4] diazepin-11-ones substituted in position 5 | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-05-22 | — | — | EP | claimed |
| US-5001122-A | Use of diazepinones for treating disorders of the microcirculation | DR. KARL THOMAE GMBH (DE) | 1991-03-19 | — | — | US | claimed |
| EP-0411567-A1 | 5-(omega-Aminoacyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-ones, processes for their preparation, and their use as medicaments | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-02-06 | — | — | EP | claimed |
| EP-0342474-A2 | Use of diazepinones for the preparation of a medicament for therapy of microcirculatory disorders | Dr. Karl Thomae GmbH (DE) | 1989-11-23 | — | — | EP | claimed |
| EP-0086980-B1 | SUBSTITUTED DIBENZODIAZEPINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1986-01-02 | — | — | EP | claimed |
| EP-0139627-A1 | Process for the preparation of 5,10-dihydro-1H-dibenzo [B,E] [1,4] diazepin-11-ones substituted in position 5 | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1985-05-02 | — | — | EP | claimed |
| EP-0086980-A1 | Substituted dibenzodiazepinones, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1983-08-31 | — | — | EP | claimed |
| EP-0044989-B1 | 5-SUBSITUTED 5,10-DIHYDRO-11H-DIBENZO(B,E)(1,4)DIAZEPIN-11-ONES, PROCESS FOR PREPARING THEM AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1983-05-25 | — | — | EP | claimed |
| EP-0044989-A1 | 5-Subsituted 5,10-dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-ones, process for preparing them and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-02-03 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197502-A1 | AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS | CHRM4, CHRM5, CHRM1 | LRRK2 2323/4885ACVR1 1494/4885PDGFRA 3209/4885 |
| US-20060252744-A1 | Use of N-desmethylclozapine and related compounds as dopamine stabilizing agents | DRD3, DRD2, PNMT | LRRK2 200/4885ACVR1 4769/4885PDGFRA 2602/4885 |
| US-20100228023-A1 | ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES | BBOX1, CYP1B1, CYP4B1 | LRRK2 4616/4885ACVR1 949/4885PDGFRA 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.