Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401973 | 0.86 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL7488520 | 0.86 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL27510542 | 0.84 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL5714681 | 0.80 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL29857922 | 0.78 | PLD1 (0.73) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL15800694 | 0.78 | PLD1 (0.73) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL21353591 | 0.78 | — | — | |
| SCHEMBL27580597 | 0.76 | ALDH1A1 (0.82) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL8981923 | 0.76 | KDM4E (0.60) | ALDH1A1SMN1; SMN2KDM4EHSD17B10POLB | |
| SCHEMBL1459007 | 0.74 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | disclosed |