Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.87 |
| ▸ | PKM | P14618 | 2/20 | 0.83 |
| ▸ | RAB9A | P51151 | 2/20 | 0.83 |
| ▸ | NPC1 | O15118 | 1/20 | 0.83 |
| ▸ | PKLR | P30613 | 1/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555472 | 1.00 | HTT (1.00) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL1044915 | 0.98 | HTT (0.96) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL1722721 | 0.91 | PKM (1.00) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL31315853 | 0.91 | PKM (1.00) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL1472052 | 0.85 | USP2 (0.77) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL16281071 | 0.84 | PKM (0.86) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL12793019 | 0.84 | ALDH1A1 (1.00) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL17007474 | 0.83 | ALDH1A1 (0.97) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL16502896 | 0.83 | ALDH1A1 (0.91) | HTTALDH1A1KDM4EPKMRAB9A | |
| SCHEMBL1352340 | 0.83 | PKM (0.77) | HTTALDH1A1KDM4EPKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109020924-B | Method for synthesizing benzene sulfonamide compound from benzene sulfonyl chloride compound and secondary amine through metal-free catalysis | 湖南农业大学 | 2022-05-13 | — | — | CN | disclosed |
| WO-2020028482-A1 | SMALL MOLECULES THAT SENSITIZE HIV-1 INFECTED CELLS TO ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-02-06 | — | — | WO | disclosed |
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
| EP-0923547-A1 | BIDENTATE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008814-A1 | BIDENTATE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | GSK3A, CDK11A, CDK1 | HTT 4489/4885ALDH1A1 1576/4885KDM4E 1457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.