Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557886 | 0.84 | KDM4E (0.47) | KIF11TAAR1KDM4EATM | |
| SCHEMBL31347506 | 0.81 | GAA (0.50) | KIF11TAAR1RAB9ALMNAHTT | |
| Hydrochloric Acid SCHEMBL8508446 | 0.81 | TAAR1 (0.42) | KIF11TAAR1LMNAKDM4EATM | |
| SCHEMBL2732542 | 0.80 | KIF11 (0.49) | KIF11KDM1ARAB9ALMNAMAPK1 | |
| SCHEMBL11280334 | 0.76 | CYP3A4 (0.44) | TAAR1KDM4EATM | |
| SCHEMBL27800149 | 0.76 | TSHR (0.53) | TAAR1RAB9ALMNAMAPK1MEN1 | |
| SCHEMBL10667796 | 0.76 | KIF11 (0.49) | KIF11KDM1ARAB9ALMNAMAPK1 | |
| SCHEMBL13413232 | 0.75 | KIF11 (0.46) | KIF11RAB9ALMNAMAPK1HTT | |
| Hydrochloric Acid SCHEMBL11286300 | 0.75 | CYP3A4 (0.43) | TAAR1KDM4EATM | |
| SCHEMBL3684692 | 0.74 | NR3C2 (0.43) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901459-A1 | CALCILYTIC COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997037967-A1 | CALCILYTIC COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 1997-10-16 | — | — | WO | disclosed |