Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 7/20 | 1.00 |
| ▸ | CDK2 | P24941 | 7/20 | 0.74 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.74 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.74 |
| ▸ | CDK1 | P06493 | 6/20 | 0.74 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.74 |
| ▸ | MPO | P05164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054835 | 0.85 | MGMT (1.00) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL14383625 | 0.80 | MGMT (0.67) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL2100316 | 0.78 | MGMT (0.63) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL2100311 | 0.77 | MGMT (0.62) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL7988070 | 0.76 | CDK2 (0.77) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL4454204 | 0.73 | CDK2 (0.66) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL2056438 | 0.72 | CCNA2 (0.67) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL16463323 | 0.71 | CDK2 (0.66) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL16464209 | 0.70 | CDK2 (0.73) | MGMTCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL8508184 | 0.69 | MGMT (0.55) | MGMTCDK2CCNA2CCNA1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929046-A | Pyrimidine and purine derivatives and their use in treating tumour cells | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |