Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.67 |
| ▸ | CDK2 | P24941 | 10/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.67 |
| ▸ | CDK1 | P06493 | 9/20 | 0.67 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.67 |
| ▸ | MGMT | P16455 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATR | Q13535 | 1/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454204 | 0.83 | CDK2 (0.66) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL16463323 | 0.81 | CDK2 (0.66) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL16465651 | 0.80 | CDK2 (1.00) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL16463170 | 0.79 | CDK2 (0.63) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL11699945 | 0.78 | CDK1 (0.54) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL29308078 | 0.77 | CDK1 (0.53) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL7988070 | 0.77 | CDK2 (0.77) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL16464209 | 0.76 | CDK2 (0.73) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL16464872 | 0.76 | CDK2 (0.63) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL8080229 | 0.76 | CDK1 (0.51) | CCNA2CDK2CCNA1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730298-B1 | SPECIFIC SUBSTRATES FOR O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | EPFL ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (CH) | 2015-11-11 | — | — | EP | disclosed |
| US-8163479-B2 | Specific substrates for O6-alkylguanine-DNA alkyltransferase | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2012-04-24 | — | — | US | disclosed |
| US-20070243568-A1 | Specific Substrates for O6-Alkylguanine-Dna Alkyltransferase | EPFL ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070243568-A1 | Specific Substrates for O6-Alkylguanine-Dna Alkyltransferase | AGT, AGXT, AGTR1 | CCNA2 193/4885CDK2 354/4885CCNA1 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.