Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacinamide SCHEMBL6371048 | 0.87 | APEX1 (0.71) | APEX1F7F3SARM1SIRT2 | |
| Niacinamide SCHEMBL8508202 | 0.80 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL3281888 | 0.78 | F7 (0.52) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL8462318 | 0.74 | F7 (0.69) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL8510801 | 0.72 | EGFR (0.42) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL15699 | 0.72 | F7 (0.56) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL22748483 | 0.72 | F7 (0.56) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL2564207 | 0.72 | F7 (0.56) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL28768072 | 0.71 | F7 (0.79) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL8414752 | 0.71 | F7 (0.52) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965106-A | ADMINISTERING TARGETING MOIETY COUPLED TO AFFINITY COMPONENT, WHEREIN TARGETING MOIETY HAS AFFINITY FOR BINDING SITES IN TARGET AREA, AND BINDING PARTNER TO AFFINITY COMPONENT COUPLED TO FUNCTIONAL MOIETY TO LOCALIZE FUNCTIONAL MOIETY IN TARGET | PERIMMUNE HOLDINGS, INC. (US) | 1999-10-12 | — | — | US | disclosed |