Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacinamide SCHEMBL8510793 | 0.87 | APEX1 (0.52) | APEX1ALDH1A1NPSR1LMNAKDM4E | |
| SCHEMBL18128747 | 0.82 | APEX1 (0.54) | APEX1ALDH1A1NPSR1LMNAKDM4E | |
| Niacinamide SCHEMBL8508206 | 0.80 | F7 (0.54) | APEX1ALDH1A1LMNAF7F3 | |
| Niacinamide SCHEMBL3281893 | 0.78 | ADORA2A (0.58) | APEX1ALDH1A1LMNAPKMF7 | |
| SCHEMBL18128748 | 0.76 | LMNA (0.48) | APEX1ALDH1A1NPSR1LMNAKDM4E | |
| SCHEMBL18128755 | 0.74 | PKM (0.48) | APEX1ALDH1A1NPSR1LMNAKDM4E | |
| Adenine SCHEMBL1324561 | 0.74 | PI4KA (0.54) | ALDH1A1LMNAHTTSMN1; SMN2HPGD | |
| Niacinamide SCHEMBL8462318 | 0.73 | F7 (0.69) | ALDH1A1F7F3SARM1SIRT2 | |
| Niacinamide SCHEMBL8510810 | 0.72 | PI4KA (0.44) | APEX1ALDH1A1LMNAF7F3 | |
| Adenine SCHEMBL15700 | 0.72 | PI4KA (0.55) | ALDH1A1LMNAHTTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336188-A | Method for the preparation of macromolecularized adenine derivatives | SNAMPROGETTI, S.P.A. (IT) | 1982-06-22 | — | — | US | claimed |
| US-4091203-A | Adenine derivatives | SNAMPROGETTI, S.P.A. (IT) | 1978-05-23 | — | — | US | claimed |
| US-20180208920-A1 | MOLECULAR MACHINES | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2018-07-26 | — | — | US | disclosed |
| EP-3325619-A1 | MOLECULAR MACHINES | Commonwealth Scientific and Industrial Research Organisation (AU) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017011870-A1 | MOLECULAR MACHINES | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2017-01-26 | — | — | WO | disclosed |
| US-20050208613-A1 | Common ligand universal enzyme assay and compositions for use therein | TRIAD THERAPEUTICS, INC. | 2005-09-22 | — | — | US | disclosed |
| US-20030228621-A1 | Common ligand universal enzyme assay and compositions for use therein | TRIAD THERAPEUTICS, INC. | 2003-12-11 | — | — | US | disclosed |
| WO-2003100078-A2 | COMMON LIGAND UNIVERSAL ENZYME AND COMPOSITIONS FOR USE THEREIN | TRIAD THERAPEUTICS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |
| US-5965106-A | ADMINISTERING TARGETING MOIETY COUPLED TO AFFINITY COMPONENT, WHEREIN TARGETING MOIETY HAS AFFINITY FOR BINDING SITES IN TARGET AREA, AND BINDING PARTNER TO AFFINITY COMPONENT COUPLED TO FUNCTIONAL MOIETY TO LOCALIZE FUNCTIONAL MOIETY IN TARGET | PERIMMUNE HOLDINGS, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-4336188-A | Method for the preparation of macromolecularized adenine derivatives | SNAMPROGETTI, S.P.A. (IT) | 1982-06-22 | — | — | US | disclosed |
| US-4199498-A | Macromolecularized adenine derivatives | SNAMPROGETTI S.P.A. (IT) | 1980-04-22 | — | — | US | disclosed |
| US-4091203-A | Adenine derivatives | SNAMPROGETTI, S.P.A. (IT) | 1978-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050208613-A1 | Common ligand universal enzyme assay and compositions for use therein | NQO1, NGFR, NTPCR | APEX1 638/4885ALDH1A1 311/4885NPSR1 255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.