Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508079 | 0.90 | MC4R (0.38) | HTR2AHTR2CHRH1PLA2G7MGLL | |
| SCHEMBL7702361 | 0.82 | OPRM1 (0.41) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL7702359 | 0.82 | OPRM1 (0.41) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL8509692 | 0.80 | CXCR4 (0.39) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL8509848 | 0.76 | CYP2A13 (0.40) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL8510483 | 0.76 | CYP2A13 (0.40) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL7702779 | 0.76 | LMNA (0.35) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL7701109 | 0.75 | TSHR (0.41) | TSHRALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL7704135 | 0.71 | GAA (0.43) | TSHR | |
| SCHEMBL7704140 | 0.71 | GAA (0.43) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |