Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 10/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8512803 | 0.99 | S1PR1 (0.42) | S1PR1KARS1HTR3EHTR3BALDH1A1 | |
| SCHEMBL8514667 | 0.91 | KARS1 (0.41) | S1PR1KARS1HTR3EHTR3BALDH1A1 | |
| Hydrochloric Acid SCHEMBL8513958 | 0.90 | KARS1 (0.41) | S1PR1KARS1HTR3EHTR3BALDH1A1 | |
| SCHEMBL8511310 | 0.89 | KARS1 (0.39) | KARS1HTR3EHTR3BALDH1A1HTR3A | |
| Hydrochloric Acid SCHEMBL8515339 | 0.89 | KARS1 (0.39) | KARS1HTR3EHTR3BALDH1A1HTR3A | |
| SCHEMBL8533609 | 0.89 | KARS1 (0.41) | KARS1HTR3EHTR3BALDH1A1HTR3A | |
| Hydrochloric Acid SCHEMBL8585525 | 0.88 | KARS1 (0.40) | KARS1HTR3EHTR3BALDH1A1HTR3A | |
| SCHEMBL8514410 | 0.86 | PIM1 (0.43) | KARS1HTR3EHTR3BALDH1A1HTR3A | |
| SCHEMBL8514673 | 0.86 | HTR3E (0.47) | KARS1HTR3EHTR3BALDH1A1HTR3A | |
| Hydrochloric Acid SCHEMBL8514770 | 0.85 | PIM1 (0.42) | KARS1HTR3EHTR3BALDH1A1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |