Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 12/20 | 0.37 |
| ▸ | FNTB | P49356 | 12/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 12/20 | 0.37 |
| ▸ | CTSL | P07711 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | CTSH | P09668 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | OTC | P00480 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL23362144 | 1.00 | FNTA (0.37) | FNTAFNTBPGGT1BCTSLCTSS | |
| Arginine SCHEMBL285822 | 0.95 | FNTA (0.35) | FNTAFNTBPGGT1BCTSLCTSS | |
| Arginine SCHEMBL13730532 | 0.92 | OTC (0.38) | OTC | |
| Arginine SCHEMBL17113849 | 0.92 | OTC (0.38) | OTC | |
| Arginine SCHEMBL176371 | 0.92 | OTC (0.38) | OTC | |
| Arginine SCHEMBL23242196 | 0.92 | OTC (0.38) | OTC | |
| Arginine SCHEMBL176372 | 0.92 | OTC (0.38) | OTC | |
| Arginine SCHEMBL17113847 | 0.92 | OTC (0.38) | OTC | |
| Arginine SCHEMBL21273831 | 0.92 | OTC (0.38) | OTC | |
| Arginine SCHEMBL1537331 | 0.92 | OTC (0.38) | OTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3131573-A1 | COMPOSITIONS COMPRISING VARIEGIN | University of Leeds (GB) | 2017-02-22 | — | — | EP | disclosed |
| US-20170035863-A1 | Compositions Comprising Variegin | UNIVERSITY OF LEEDS (GB) | 2017-02-09 | — | — | US | disclosed |
| WO-2015159084-A1 | COMPOSITIONS COMPRISING VARIEGIN | UNIVERSITY OF LEEDS (GB) | 2015-10-22 | — | — | WO | disclosed |
| US-20120135931-A1 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2012-05-31 | — | — | US | disclosed |