Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 12/20 | 0.35 |
| ▸ | FNTB | P49356 | 12/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 12/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSH | P09668 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | NPY4R | P50391 | 2/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL23362144 | 0.95 | FNTA (0.37) | FNTAFNTBPGGT1BCTSLCTSS | |
| Arginine SCHEMBL8512347 | 0.95 | FNTA (0.37) | FNTAFNTBPGGT1BCTSLCTSS | |
| Arginine SCHEMBL8510534 | 0.93 | CTSL (0.31) | FNTAFNTBPGGT1BCTSLCTSS | |
| Arginine SCHEMBL27607779 | 0.87 | APLNR (0.36) | FNTAFNTBPGGT1BCTSLCTSS | |
| Arginine SCHEMBL17113849 | 0.87 | OTC (0.38) | NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL176372 | 0.87 | OTC (0.38) | NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL13730532 | 0.87 | OTC (0.38) | NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL17113847 | 0.87 | OTC (0.38) | NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL21273831 | 0.87 | OTC (0.38) | NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL23242196 | 0.87 | OTC (0.38) | NPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135931-A1 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2012-05-31 | — | — | US | disclosed |
| EP-2427487-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | Natural Environment Research Council (GB) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128285-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2010-11-11 | — | — | WO | disclosed |