Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL1643487 | 0.97 | CA4 (0.52) | CA4LMNAPDE4AL3MBTL1TDP1 | |
| Citric Acid SCHEMBL28000818 | 0.97 | CA4 (0.52) | CA4LMNAPDE4AL3MBTL1TDP1 | |
| Citric Acid SCHEMBL27610616 | 0.97 | CA4 (0.52) | CA4LMNAPDE4AL3MBTL1TDP1 | |
| Citric Acid SCHEMBL873958 | 0.97 | CA4 (0.52) | CA4LMNAPDE4AL3MBTL1TDP1 | |
| Citric Acid SCHEMBL7911623 | 0.88 | CA4 (0.42) | CA4LMNAPDE4A | |
| Citric Acid SCHEMBL25267224 | 0.87 | CA4 (0.61) | CA4LMNAPDE4AL3MBTL1TDP1 | |
| Citric Acid SCHEMBL60075 | 0.87 | CA4 (0.61) | CA4LMNAPDE4AL3MBTL1TDP1 | |
| Citric Acid SCHEMBL21807344 | 0.85 | CA4 (0.65) | CA4LMNAPDE4AL3MBTL1TDP1 | |
| Citric Acid SCHEMBL21807340 | 0.85 | CA4 (0.65) | CA4LMNAPDE4AL3MBTL1TDP1 | |
| Citric Acid SCHEMBL30809599 | 0.82 | CA4 (0.59) | CA4LMNAPDE4AL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140302482-A1 | ELECTROMAGNETIC BLOOD PRESERVATION AND STORAGE | 98.6 RESEARCH LLC | 2014-10-09 | — | — | US | disclosed |
| US-20140255906-A1 | ELECTROMAGNETIC BLOOD PRESERVATION AND STORAGE | 98.6 RESEARCH LLC | 2014-09-11 | — | — | US | disclosed |
| WO-2012071568-A2 | ELECTROMAGNETIC BLOOD PRESERVATION AND STORAGE | 98.6 RESEARCH LLC (US) | 2012-05-31 | — | — | WO | disclosed |