Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28000818 | 0.91 | CA4 (0.52) | CA4LMNAPDE4A | |
| Citric Acid SCHEMBL1643487 | 0.91 | CA4 (0.52) | CA4LMNAPDE4A | |
| Citric Acid SCHEMBL27610616 | 0.91 | CA4 (0.52) | CA4LMNAPDE4A | |
| Citric Acid SCHEMBL873958 | 0.91 | CA4 (0.52) | CA4LMNAPDE4A | |
| Citric Acid SCHEMBL29143181 | 0.90 | LMNA (0.37) | CA4LMNAALDH1A1 | |
| Citric Acid SCHEMBL8512435 | 0.88 | CA4 (0.47) | CA4LMNAPDE4A | |
| Citric Acid SCHEMBL1860526 | 0.88 | ALDH1A1 (0.46) | LMNAALDH1A1PDE4A | |
| Citric Acid SCHEMBL50630 | 0.88 | ALDH1A1 (0.48) | LMNAALDH1A1PDE4A | |
| Citric Acid SCHEMBL20271528 | 0.88 | ALDH1A1 (0.48) | LMNAALDH1A1PDE4A | |
| Citric Acid SCHEMBL20338075 | 0.88 | ALDH1A1 (0.48) | LMNAALDH1A1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329498-B1 | AMINO ACID SEQUENCE; STABLE PREPARATION FOR TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS | SEIKAGAKU CORPORATION (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1016672-A1 | POLYPEPTIDE TRANSITION METAL SALTS AND METHOD OF ENHANCING ANTI-HIV ACTIVITY OF POLYPEPTIDE | SEIKAGAKU CORPORATION (JP) | 2000-07-05 | — | — | EP | disclosed |
| US-5614106-A | Method and apparatus for collection of platelets | BAXTER INTERNATIONAL INC. (US) | 1997-03-25 | — | — | US | disclosed |