SCHEMBL851353

SCHEMBL851353

C=C(C(N)=O)C(CC)[Si](O[SiH2]c1cccc(C)c1C)(O[SiH2]c1cccc(C)c1C)O[SiH2]c1cccc(C)c1C

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.32
LMNA P02545 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL851112 0.76 GAA (0.33) HTTLMNA
SCHEMBL1517424 0.75 ACACB (0.34) HTTLMNA
SCHEMBL10535392 0.68 TRPA1 (0.36) LMNA
SCHEMBL851910 0.67
SCHEMBL247511 0.67 TRPA1 (0.31)
SCHEMBL2170804 0.66 ALOX15 (0.31)
SCHEMBL2248050 0.66 TRPA1 (0.35)
SCHEMBL11809799 0.66 TRPA1 (0.34) HTTLMNA
SCHEMBL11808939 0.65 GAA (0.38) LMNA
SCHEMBL9938501 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2432808-A1 ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS Novartis AG (CH) 2012-03-28 EP claimed
WO-2010133680-A1 ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS NOVARTIS AG (CH) 2010-11-25 WO claimed