Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1162286 | 0.85 | CYP1B1 (0.37) | CTSATP53PDE2APDE10A | |
| SCHEMBL1162305 | 0.80 | CYP1A2 (0.34) | CTSAMEN1KMT2AL3MBTL1PDE2A | |
| SCHEMBL1162377 | 0.80 | CYP1A2 (0.34) | CTSATP53AKR1C3AKR1C2WDR5 | |
| SCHEMBL1162395 | 0.79 | CYP1A2 (0.41) | CTSAMEN1KMT2AFFAR1TDP1 | |
| SCHEMBL1593482 | 0.79 | TP53 (0.44) | CTSATP53AKR1C3AKR1C2PTGS2 | |
| SCHEMBL1162608 | 0.77 | CYP1A1 (0.36) | CTSATP53MEN1PKMKMT2A | |
| SCHEMBL1162406 | 0.76 | CYP1A2 (0.33) | CTSAMEN1KMT2AL3MBTL1PDE2A | |
| SCHEMBL1938749 | 0.75 | ADORA2A (0.46) | TP53MEN1KMT2AMAPTTHRB | |
| SCHEMBL8510090 | 0.74 | AKR1C3 (0.36) | TP53AKR1C3AKR1C2PTGS2MEN1 | |
| SCHEMBL1937723 | 0.73 | ABL1 (0.38) | TP53MAPTPDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135995-A1 | FUNGICIDAL DIPHENYL-SUBSTITUTED PYRIDAZINES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135995-A1 | FUNGICIDAL DIPHENYL-SUBSTITUTED PYRIDAZINES | PNPO, CYP1B1, PRXL2A | CTSA 1218/4885TP53 3523/4885AKR1C3 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.