Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26422848 | 0.92 | LMNA (0.50) | LMNAKDM4EGAAMAPTIDO1 | |
| SCHEMBL25009716 | 0.84 | KDM4E (0.53) | LMNAKDM4EGAAMAPTIDO1 | |
| SCHEMBL82951 | 0.84 | BRD4 (0.47) | LMNAKDM4EGAAMAPTMEN1 | |
| SCHEMBL25039341 | 0.84 | LMNA (0.44) | LMNAKDM4EGAAMAPTGRIN2D | |
| SCHEMBL15163867 | 0.84 | LMNA (0.44) | LMNAKDM4EGAAMAPTGRIN2D | |
| Hydrochloric Acid SCHEMBL69480 | 0.83 | BRD4 (0.46) | LMNAKDM4EGAAMAPTMEN1 | |
| SCHEMBL3105796 | 0.80 | LMNA (0.47) | LMNAKDM4EGAAKMT2AGRIN2D | |
| SCHEMBL11521138 | 0.80 | KDM4E (0.69) | LMNAKDM4EGAAMAPTIDO1 | |
| SCHEMBL24786811 | 0.79 | LMNA (0.50) | LMNAKDM4EGAAMAPTIDO1 | |
| SCHEMBL20336230 | 0.78 | KDM4E (0.73) | LMNAKDM4EGAAMAPTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |