Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533516 | 0.86 | CREBBP (0.38) | CREBBPPIK3CAGPR142USP2POLB | |
| SCHEMBL8535612 | 0.80 | PIK3CA (0.35) | CREBBPPIK3CA | |
| SCHEMBL9290706 | 0.80 | CREBBP (0.36) | CREBBPPIK3CAGPR142USP2POLB | |
| SCHEMBL15407782 | 0.78 | PIK3CA (0.36) | CREBBPPIK3CANUDT1 | |
| SCHEMBL8532787 | 0.78 | PIK3CA (0.41) | CREBBPPIK3CANUDT1 | |
| SCHEMBL8516266 | 0.76 | PIK3CA (0.38) | CREBBPPIK3CA | |
| SCHEMBL3754735 | 0.76 | PIK3CA (0.41) | CREBBPPIK3CANUDT1GPR142 | |
| SCHEMBL2727963 | 0.76 | CREBBP (0.48) | CREBBPPIK3CAGPR142 | |
| SCHEMBL9281817 | 0.74 | PIK3CA (0.41) | PIK3CA | |
| SCHEMBL856227 | 0.74 | PIK3CA (0.33) | CREBBPPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643315-A1 | BENZOXAZEPINES AS INHIBITORS OF P13K/mTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-10-02 | — | — | EP | claimed |
| WO-2012071501-A1 | BENZOXAZEPINES ASN INHIBITORS OF P13K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-31 | — | — | WO | claimed |