Sugi Predict

Sugi Predict / Compounds / SCHEMBL8514563

SCHEMBL8514563

SCHEMBL8514563

O=C(O)NC1CCN(c2ccccc2)C1=O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FPR2 P25090 5/20 0.64
▸ FPR1 P21462 2/20 0.64
▸ HDAC6 Q9UBN7 6/20 0.58
▸ HDAC8 Q9BY41 5/20 0.58
▸ HDAC1 Q13547 3/20 0.58
▸ CA12 O43570 1/20 0.52
▸ CA1 P00915 1/20 0.52
▸ CA2 P00918 1/20 0.52
▸ CA9 Q16790 1/20 0.52
▸ USP30 Q70CQ3 1/20 0.47
▸ ROCK2 O75116 2/20 0.44
▸ DDB1 Q16531 2/20 0.44
▸ CRBN Q96SW2 2/20 0.44
▸ ROCK1 Q13464 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ ITGB3 P05106 1/20 0.42
▸ ITGA2B P08514 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3495094 0.91 FPR2 (0.54) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL6360474 0.87 FPR2 (0.52) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL5219240 0.86 FPR2 (0.64) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL16468268 0.86 FPR2 (0.67) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL19471943 0.86 HDAC1 (0.61) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL19471942 0.86 HDAC1 (0.61) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL6361911 0.83 HDAC1 (0.47) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL6366522 0.83 FPR2 (0.47) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL26454359 0.82 FPR2 (0.61) FPR2FPR1HDAC6HDAC8HDAC1
SCHEMBL25090839 0.81 FPR2 (0.54) FPR2FPR1HDAC6HDAC8HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230286954-A1 PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2023-09-14 — — US disclosed
US-11680057-B2 Pyrazole derivatives SYNGENTA CROP PROTECTION AG (CH) 2023-06-20 — — US disclosed
EP-3663282-B1 PYRROLIDINONE HERBICIDES FMC CORP (US) 2022-05-18 — — EP disclosed
EP-3921306-A2 PYRAZOLE DERIVATIVES Syngenta Crop Protection AG (CH) 2021-12-15 — — EP disclosed
CN-113412254-A Pyrazole derivatives 先正达农作物保护股份公司 2021-09-17 — — CN disclosed
US-11059806-B2 Pyrazole derivatives SYNGENTA CROP PROTECTION AG (CH) 2021-07-13 — — US disclosed
US-20210147389-A1 PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2021-05-20 — — US disclosed
EP-3164386-B1 PIPERIDINONE HERBICIDES FMC CORP (US) 2020-10-07 — — EP disclosed
WO-2020161148-A2 PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2020-08-13 — — WO disclosed
US-20200245625-A1 PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2020-08-06 — — US disclosed
WO-1993003615-A1 SAFENING HERBICIDAL PYRAZOLYLSULFONYLURES MONSANTO COMPANY (US) 1993-03-04 — — WO disclosed
WO-1992011761-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1992-07-23 — — WO disclosed
WO-1992010098-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1992-06-25 — — WO disclosed
EP-0480902-A1 Safening herbicidal benzoic acid derivatives MONSANTO COMPANY (US) 1992-04-15 — — EP disclosed
EP-0451168-A1 1-PHENYL-3-CARBOXYAMIDOPYRROLIDONES AND THEIR USE AS HERBICIDES. ICI AMERICA INC (US) 1991-10-16 — — EP disclosed
WO-1990007500-A1 1-PHENYL-3-CARBOXYAMIDOPYRROLIDONES AND THEIR USE AS HERBICIDES ICI AMERICAS INC. (US) 1990-07-12 — — WO disclosed
WO-1990007500-A1 1-PHENYL-3-CARBOXYAMIDOPYRROLIDONES AND THEIR USE AS HERBICIDES ICI AMERICAS INC. (US) 1990-07-12 — — WO disclosed
US-4874422-A 1-Phenyl-3-carboxyamidopyrrolidones and their use as herbicides ICI AMERICAS INC. (US) 1989-10-17 — — US disclosed
US-4874422-A 1-Phenyl-3-carboxyamidopyrrolidones and their use as herbicides ICI AMERICAS INC. (US) 1989-10-17 — — US disclosed
US-4874422-A 1-Phenyl-3-carboxyamidopyrrolidones and their use as herbicides ICI AMERICAS INC. (US) 1989-10-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230286954-A1 PYRAZOLE DERIVATIVES RB1, NQO2, RBX1 FPR2 1559/4885FPR1 1902/4885HDAC6 1572/4885
US-11680057-B2 Pyrazole derivatives RB1, NQO2, RBX1 FPR2 1559/4885FPR1 1902/4885HDAC6 1572/4885
US-20210147389-A1 PYRAZOLE DERIVATIVES RB1, NQO2, RBX1 FPR2 1559/4885FPR1 1902/4885HDAC6 1572/4885
US-20200245625-A1 PYRAZOLE DERIVATIVES RB1, NQO2, RBX1 FPR2 1559/4885FPR1 1902/4885HDAC6 1572/4885
US-11059806-B2 Pyrazole derivatives RB1, NQO2, RBX1 FPR2 1559/4885FPR1 1902/4885HDAC6 1572/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.