Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 4/20 | 0.52 |
| ▸ | FPR1 | P21462 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8514563 | 0.87 | FPR2 (0.64) | FPR2FPR1HDAC6HDAC8HDAC1 | |
| SCHEMBL16468268 | 0.81 | FPR2 (0.67) | FPR2FPR1HDAC6HDAC8HDAC1 | |
| SCHEMBL5219240 | 0.81 | FPR2 (0.64) | FPR2FPR1HDAC6HDAC8HDAC1 | |
| SCHEMBL3495094 | 0.79 | FPR2 (0.54) | FPR2FPR1HDAC6HDAC8HDAC1 | |
| SCHEMBL11030267 | 0.78 | HDAC6 (0.81) | HDAC6HDAC8HDAC1ROCK2CA12 | |
| SCHEMBL6361911 | 0.77 | HDAC1 (0.47) | FPR2FPR1HDAC6HDAC8HDAC1 | |
| SCHEMBL6366522 | 0.77 | FPR2 (0.47) | FPR2FPR1HDAC6HDAC8HDAC1 | |
| SCHEMBL3508153 | 0.75 | MAOB (0.50) | FPR2FPR1ALDH1A1 | |
| SCHEMBL3508151 | 0.75 | MAOB (0.50) | FPR2FPR1ALDH1A1 | |
| SCHEMBL19471943 | 0.75 | HDAC1 (0.61) | FPR2FPR1HDAC6HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059726-A1 | Pyrrolidine-2-ones as factor xa inhibitors | GLAXO GROUP LIMITED (GB) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059726-A1 | Pyrrolidine-2-ones as factor xa inhibitors | TFPI, F2, SERPINC1 | FPR2 371/4885FPR1 641/4885HDAC6 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.