Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | OGA | O60502 | 1/20 | 0.43 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27739912 | 0.87 | HRH3 (0.52) | ADRA1AKMT2AAOC3HRH3NPC1 | |
| SCHEMBL31026061 | 0.87 | HRH3 (0.52) | ADRA1AKMT2AAOC3HRH3NPC1 | |
| SCHEMBL8589172 | 0.87 | HRH3 (0.52) | ADRA1AKMT2AAOC3HRH3NPC1 | |
| SCHEMBL16846259 | 0.85 | KMT2A (0.57) | ADRA1AKMT2AAOC3HRH3ALDH1A1 | |
| SCHEMBL17128144 | 0.85 | KMT2A (0.57) | ADRA1AKMT2AAOC3HRH3ALDH1A1 | |
| SCHEMBL17560141 | 0.82 | HRH3 (0.45) | ADRA1AKMT2AHRH3LMNAALDH1A1 | |
| SCHEMBL15546819 | 0.82 | HRH3 (0.47) | ADRA1AKMT2AHRH3LMNAALDH1A1 | |
| SCHEMBL16824367 | 0.80 | POLB (0.55) | KMT2AAOC3ALDH1A1HPGDNPC1 | |
| SCHEMBL20220389 | 0.80 | POLB (0.55) | KMT2AAOC3ALDH1A1HPGDNPC1 | |
| SCHEMBL30744925 | 0.80 | LMNA (0.48) | KMT2AHRH3LMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624198-B2 | Substituted piperidinyltetrahydroquinolines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-04-18 | — | — | US | disclosed |
| US-9624198-B2 | Substituted piperidinyltetrahydroquinolines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-04-18 | — | — | US | disclosed |
| US-9624198-B2 | Substituted piperidinyltetrahydroquinolines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-04-18 | — | — | US | disclosed |
| EP-3083593-A1 | SUBSTITUTED PIPERIDINYL-TETRAHYDROQUINOLINES | Bayer Pharma Aktiengesellschaft (DE) | 2016-10-26 | — | — | EP | disclosed |
| US-20160304491-A1 | SUBSTITUTED PIPERIDINYLTETRAHYDROQUINOLINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160304491-A1 | SUBSTITUTED PIPERIDINYLTETRAHYDROQUINOLINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160304491-A1 | SUBSTITUTED PIPERIDINYLTETRAHYDROQUINOLINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-10-20 | — | — | US | disclosed |
| WO-2015091417-A1 | SUBSTITUTED PIPERIDINYL-TETRAHYDROQUINOLINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015091417-A1 | SUBSTITUTED PIPERIDINYL-TETRAHYDROQUINOLINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-06-25 | — | — | WO | disclosed |
| EP-2456422-A2 | TOPICAL PHARMACEUTICAL COMPOSITION INCLUDING REL-N-[6-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-3-PYRIDINYL]-2-METHYL-41-(TRIFLUOROMETHOXY)-[1,1'-BIPHENYL]-3-CARBOXAMIDE. | Novartis AG (CH) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011009852-A3 | TOPICAL PHARMACEUTICAL COMPOSITION INCLUDING REL-N- [6 - [ (2R, 6S) - 2, 6 - DIMETHYL - 4 -MORPHOLINYL] -3 - PYRIDINYL] - 2 -METHYL -41 (TRIFLUOROMETHOXY) - [1,1' -BIPHENYL] - 3 - CARBOXAMIDE | NOVARTIS AG (CH) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304491-A1 | SUBSTITUTED PIPERIDINYLTETRAHYDROQUINOLINES | TNNI3, TNNC1, PRPH | ADRA1A 1949/4885KMT2A 4647/4885AOC3 3648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.