Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DKK1 | O94907 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | RARG | P13631 | 2/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2049616 | 0.85 | HRH3 (0.49) | KARS1HRH3DYRK1AWNT1GSK3B | |
| Hydrochloric Acid SCHEMBL8514877 | 0.84 | HRH3 (0.48) | KARS1HRH3DYRK1AWNT1GSK3B | |
| SCHEMBL8510961 | 0.83 | DKK1 (0.43) | KARS1PIM1HRH3DKK1LRRK2 | |
| SCHEMBL2016664 | 0.82 | DYRK1A (0.54) | KARS1DYRK1A | |
| SCHEMBL8514846 | 0.82 | DKK1 (0.49) | KARS1PIM1DYRK1ADKK1IRAK4 | |
| SCHEMBL8515149 | 0.82 | RARA (0.49) | KARS1PIM1HRH3DKK1PAK4 | |
| Hydrochloric Acid SCHEMBL2015173 | 0.81 | RARA (0.48) | KARS1PIM1HRH3DKK1PAK4 | |
| Hydrochloric Acid SCHEMBL8515557 | 0.81 | RARA (0.48) | KARS1PIM1HRH3DKK1PAK4 | |
| SCHEMBL8514245 | 0.81 | DYRK1A (0.47) | PIM1DYRK1ACKS1BSKP1SKP2 | |
| SCHEMBL8514868 | 0.81 | DKK1 (0.64) | KARS1HRH3DYRK1ADKK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |