Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358090 | 0.84 | MAPT (0.54) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL11261037 | 0.76 | MAPT (0.64) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8352629 | 0.76 | MAPT (0.59) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8350635 | 0.76 | MAPT (0.58) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8358204 | 0.76 | ALDH1A1 (0.58) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8354375 | 0.75 | SMN1; SMN2 (0.68) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8353724 | 0.74 | ALDH1A1 (0.56) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8353854 | 0.74 | ALDH1A1 (0.66) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8354500 | 0.74 | MAPT (0.61) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8358040 | 0.74 | ALDH1A1 (0.61) | MAPTALDH1A1KDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |