Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6677769 | 0.98 | GBA1 (0.51) | GBA1DDB1CRBNMAOBHDAC8 | |
| SCHEMBL837901 | 0.79 | DDB1 (0.60) | GBA1DDB1CRBNMAOBHDAC8 | |
| SCHEMBL3263571 | 0.77 | GBA1 (0.50) | GBA1DDB1CRBNMAOBPOLB | |
| SCHEMBL3263577 | 0.77 | GBA1 (0.50) | GBA1DDB1CRBNMAOBPOLB | |
| SCHEMBL29016897 | 0.76 | DDB1 (0.61) | GBA1DDB1CRBNMAOBHSD11B1 | |
| SCHEMBL29013938 | 0.73 | DDB1 (0.52) | DDB1CRBNMAOBHDAC8POLB | |
| SCHEMBL23056654 | 0.73 | PTGS2 (0.59) | DDB1CRBNHSD11B1 | |
| SCHEMBL29169544 | 0.73 | PTGS2 (0.59) | DDB1CRBNHSD11B1 | |
| SCHEMBL793526 | 0.73 | PTGS2 (0.59) | DDB1CRBNHSD11B1 | |
| SCHEMBL27647515 | 0.72 | GBA1 (0.33) | GBA1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1136475-B1 | Piperidine and piperazine compounds for use in the treatment of Alzheimer | HOFFMANN LA ROCHE (CH) | 2004-08-18 | — | — | EP | disclosed |