SCHEMBL8515848

SCHEMBL8515848

Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCc4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1

nearest known ligand 0.77

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8365936 0.90 BDKRB2 (0.63) BDKRB2
SCHEMBL657025 0.88 BDKRB2 (0.77) BDKRB2
SCHEMBL8367942 0.87 BDKRB2 (1.00) BDKRB2
SCHEMBL8367940 0.87 BDKRB2 (1.00) BDKRB2
SCHEMBL8367340 0.85 BDKRB2 (0.56) BDKRB2
SCHEMBL658464 0.83 BDKRB2 (0.68) BDKRB2
SCHEMBL656991 0.83 BDKRB2 (0.65) BDKRB2
SCHEMBL660804 0.82 BDKRB2 (0.77) BDKRB2
SCHEMBL658796 0.82 BDKRB2 (0.62) BDKRB2
SCHEMBL8366125 0.82 BDKRB2 (0.88) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed