Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | AGER | Q15109 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15142659 | 0.84 | SMN1; SMN2 (0.40) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL5524278 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL126180 | 0.82 | MEN1 (0.54) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL1101604 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL8515791 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL459180 | 0.81 | MAPT (0.47) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL28269519 | 0.81 | L3MBTL1 (0.54) | KDM4EALDH1A1ALOX15L3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL17028445 | 0.81 | MEN1 (0.52) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL1138239 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL4425717 | 0.79 | KDM4E (0.57) | KDM4EALDH1A1MAPTALOX15L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456763-A1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Novartis AG (CH) | 2012-05-30 | — | — | EP | claimed |
| EP-2456763-A1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Novartis AG (CH) | 2012-05-30 | — | — | EP | disclosed |