Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 20/20 | 0.89 |
| ▸ | BCL2 | P10415 | 11/20 | 0.89 |
| ▸ | MDM4 | O15151 | 1/20 | 0.89 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.89 |
| ▸ | TP53 | P04637 | 1/20 | 0.89 |
| ▸ | BID | P55957 | 1/20 | 0.89 |
| ▸ | BAX | Q07812 | 1/20 | 0.89 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.89 |
| ▸ | ASPH | Q12797 | 1/20 | 0.89 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.89 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.89 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.89 |
| ▸ | BAD | Q92934 | 1/20 | 0.89 |
| ▸ | BBC3 | Q9BXH1 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3426272 | 1.00 | BCL2L1 (0.89) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL26648001 | 0.95 | BCL2L1 (0.90) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL31450804 | 0.95 | BCL2L1 (0.90) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL26648832 | 0.95 | BCL2L1 (0.90) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| Abt 737 SCHEMBL1541072 | 0.94 | BCL2L1 (1.00) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| Abt 737 SCHEMBL170470 | 0.94 | BCL2L1 (1.00) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| Abt 737 SCHEMBL29355185 | 0.94 | BCL2L1 (1.00) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| Abt 737 SCHEMBL158942 | 0.94 | BCL2L1 (1.00) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL1541099 | 0.94 | BCL2L1 (0.88) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL26647885 | 0.94 | BCL2L1 (0.88) | BCL2L1BCL2MDM4BCL2L11TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442584-A1 | COMBINATIONS OF PBD-BASED ANTIBODY DRUG CONJUGATES WITH BCL-2 INHIBITORS | Seattle Genetics, Inc. (US) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017160954-A1 | COMBINATIONS OF PBD-BASED ANTIBODY DRUG CONJUGATES WITH BCL-2 INHIBITORS | SEATTLE GENETICS, INC. (US) | 2017-09-21 | — | — | WO | disclosed |
| WO-2016079067-A1 | COMPOUNDS TARGETING THE BFL-1 ANTI-APOPTOTIC PROTEIN AND USES THEREOF FOR THE TREATMENT OF CANCER | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2016-05-26 | — | — | WO | disclosed |
| EP-2643322-A1 | SALTS AND CRYSTALLINE FORMS OF AN APOPTOSIS-INDUCING AGENT | Abbvie Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012071336-A1 | SALTS AND CRYSTALLINE FORMS OF AN APOPTOSIS-INDUCING AGENT | ABBOTT LABORATORIES (US) | 2012-05-31 | — | — | WO | disclosed |