SCHEMBL8516636

SCHEMBL8516636

C=CC(=O)OCC[N+](C)(C)C.CS(=O)(=O)[O-]

nearest known ligand 0.46

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 known ✓ P11229 6/20 0.46
HTR1A known ✓ P08908 2/20 0.46
ADRA2A known ✓ P08913 1/20 0.46
ADRA1A known ✓ P35348 1/20 0.46
CHRNA10 known ✓ Q9GZZ6 1/20 0.46
CHRNA9 known ✓ Q9UGM1 1/20 0.46
TSHR P16473 6/20 0.46
HPGD P15428 1/20 0.46
CHRM5 P08912 6/20 0.46
CHRM3 P20309 6/20 0.46
CHRM2 P08172 5/20 0.46
CHRM4 P08173 5/20 0.46
CHRNB2 P17787 4/20 0.46
CHRNA4 P43681 4/20 0.46
ALDH1A1 P00352 3/20 0.46
CHRNA7 P36544 3/20 0.46
TP53 P04637 2/20 0.46
HIF1A Q16665 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28171146 1.00 TSHR (0.46) TSHRHPGDCHRM5CHRM1CHRM3
Sulfuric Acid SCHEMBL1952726 0.95 TSHR (0.47) TSHRHPGDCHRM5CHRM1CHRM3
Sulfuric Acid SCHEMBL1952728 0.93 TSHR (0.46) TSHRHPGDCHRM5CHRM1CHRM3
Sulfuric Acid SCHEMBL31228302 0.93 CHRM5 (0.48) TSHRHPGDCHRM5CHRM1CHRM3
Sulfuric Acid SCHEMBL27725119 0.92 TSHR (0.44) TSHRHPGDCHRM5CHRM1CHRM3
Sulfuric Acid SCHEMBL27994079 0.90 TSHR (0.46) TSHRHPGDCHRM5CHRM1CHRM3
SCHEMBL304033 0.90 TSHR (0.43) TSHRHPGDCHRM5CHRM1CHRM3
Sulfuric Acid SCHEMBL2790952 0.89 TSHR (0.48) TSHRHPGDCHRM5CHRM1CHRM3
SCHEMBL25422044 0.89 TSHR (0.56) TSHRHPGDCHRM5CHRM1CHRM3
SCHEMBL20908 0.89 TSHR (0.56) TSHRHPGDCHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999050500-A1 IMPROVING RETENTION AND DRAINAGE IN ALKALINE FINE PAPER CALLAWAY CORPORATION (US) 1999-10-07 WO disclosed